Lamivudine is an antiviral agent used in the treatment of AIDS having moderate half-life of 5-7 hours thus it is a good candidate for the formulation of sustained release dosage forms. In the present work lamivudine loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). Nanoparticles of different core: coat ratio were formulated and evaluated for drug content, loading efficiency, particle size, zeta potential, invitro drug release and stability studies. SEM indicated that the nanoparticles were found to be in nanometer range and showed ideal surface morphology. FT-IR studies indicated that their was no chemical interactions between drug and polymer and stability of drug. The invitro release behaviour from all the drug loaded batches were found to follow zero order and provided sustained release over a period of 24 hr. No appreciable difference was observed in the extent of degradation of product during 60 days in which nanoparticles were stored at various temperatures. The developed formulation overcome and alleviates the drawbacks and limitations of lamivudine conventional dosage forms and could possibility be advantageous in terms of increased bioavailability of lamivudine.
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